Opioid Activities of Morphiceptin Analogs Derived from Human β-Casein
نویسندگان
چکیده
منابع مشابه
Epigenetic effects of casein-derived opioid peptides in SH-SY5Y human neuroblastoma cells.
BACKGROUND Casein-free, gluten-free diets have been reported to mitigate some of the inflammatory gastrointestinal and behavioral traits associated with autism, but the mechanism for this palliative effect has not been elucidated. We recently showed that the opioid peptide beta-casomorphin-7, derived from bovine (bBCM7) milk, decreases cysteine uptake, lowers levels of the antioxidant glutathio...
متن کاملCharacterization of casein hydrolysates derived from enzymatic hydrolysis
BACKGROUND Casein is the main proteinaceous component of milk and has made us interest due to its wide applications in the food, drug, and cosmetic industries as well as to its importance as an investigation material for elucidating essential questions regarding the protein chemistry. Enzymatic hydrolysis is an important method commonly used in the modification of protein structure in order to ...
متن کاملDual effect of morphiceptin on lordosis behavior: possible mediation by different opioid receptor subtypes.
Intracerebroventricular (ICV) infusions of the selective mu receptor agonist morphiceptin produce a dual effect on lordosis behavior in ovariectomized, steroid-primed rats. Low doses of morphiceptin (20 ng) inhibit lordosis whereas higher doses (2000 ng) facilitate this behavior. The present experiment tested whether naloxone, an antagonist of both high- and low-affinity mu receptors, or the lo...
متن کاملthe biologic effects of casein and casein-derived bioactive peptides
casein possesses important physiological and biological properties with regard to promotion of health, as well as prevention of diseases. anticarcinogenic activities, reduction in the risk factors of cardiovascular disease and anticariogenic features have been associated with casein. in addition, casein is known as a source of bioactive peptides. casein-derived peptides have been found to have ...
متن کاملOpioid Peptides Derived from Food Proteins
Peptides with opioid activity are found in pepsin hydrolysates of wheat gluten and a-casein. The opioid activity of these peptides was demonstrated by use of the following bioassays: 1) naloxone-reversible inhibition of adenylate cyclase in homogenates of neuroblastoma X-glioma hybrid cells; 2) naloxone-reversible inhibition of electrically stimulated contractions of the mouse vas deferens; 3) ...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1990
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.63.1753